Model testing for distinctive functional connectivity gradients with resting-state fMRI data

A Longitudinal Model for Functional Connectivity Using Resting-State fMRI

Many neuroimaging studies collect functional magnetic resonance imaging (fMRI) data in a longitudinal manner. The current fMRI modeling literature lacks a generally applicable model appropriate for longitudinal designs. In this work, we build a novel longitudinal functional connectivity (FC) model using a variance components approach. First, for all subjects’ visits, we account for the autocorr...

Brain Connections – Resting State fMRI Functional Connectivity

With the introduction of electroencephalography (EEG) in 1930, researchers began to explore spontaneous activity in the brain by recording the individual, independently of any task. Subsequently, evoked potential studies, where electrical potentials were recorded at the onset of a stimulus, marked a milestone in brain research. Utilizing such methods coupled with experimental psychology, resear...

Support vector classification analysis of resting state functional connectivity fMRI

Vascular Modulation of Resting-State fMRI Functional Connectivity

Widely used in resting-state fMRI functional connectivity measurement (fcMRI), the BOLD signal is an indirect measure of neuronal activity, inherently modulated by vascular physiology. Notably, cerebrovascular reactivity (CVR) varies across individuals irrespective of neuronal changes, with unknown implications, compromising fcMRI interpretation. This work quantifies the relationship between CV...

Resting State fMRI Functional Connectivity Analysis Using Dynamic Time Warping

Traditional resting-state network concept is based on calculating linear dependence of spontaneous low frequency fluctuations of the BOLD signals of different brain areas, which assumes temporally stable zero-lag synchrony across regions. However, growing amount of experimental findings suggest that functional connectivity exhibits dynamic changes and a complex time-lag structure, which cannot ...